Endocrine Abstracts

Background: In spite of being the most frequent genetic form of male hypogonadism, Klinefelter’s syndrome is not so rarely undiagnosed until adulthood. As the severity of manifestations in Klinefelter’s syndrome is proportional to the number of additional X chromosomes, they seem less severe and aparent in its classic form, with a 47,XXY karyotype than in cases of this syndrome with mosaicism and other variants.Case report: A 25-year-old male w...

Background: The association of antiphospholipid syndrome (APS) with various endocrine disorders is already known. However, data on the influence of thyroid autoantibodies and/or disorders of thyroid function on the expression of classical APS manifestations are rather limited.Objectives: The aim of this investigation was to evaluate the impact of thyroid autoimmunity and dysfunction on frequency of recurrent miscarriages in patients with primary antiphos...

Background: Adrenal incidentalomas (AI) represent incidentaly discovered adrenal mases, without simptoms or signs suggestive of adrenal pathology, at the time of visualization. It is well-known that overt or subclinical hypercorticism, as well as metabolic syndrome (MetS) harbour increased CV risk.There is still persisting debate on eventual cause-effect relationship of AI with metabolic syndrome MetS or probability of simply more frequent occurance of AI among these patients....

The metabolic syndrome resembles Cushing’s syndrome in several clinical aspects. Main characteristic of both syndromes is obesity assessed by the body mass index (BMI) or waist circumference (WC).The aim of this study was to investigate cortisol dynamics in 20 healthy volunteers (BMI<27 kg/m2; 13 females, 7 males, age 42.1+12.39 years) and 20 obese patients (BMI≥27 kg/m2; 13 females, 7 males, age 49.25+1...

Background and aims: Plasminogen activator inhibitor -1 (PAI-1) increases in diabetes and this might contribute to decreased fibrinolisis and accelerated atherosclerosis. PAI-1 is also contributor to the development of acute myocardial infarction. Measurement of intimal medial thickening (IMT) is indicator of presence and extent of coronary artery disease. Aim of the study was to find association between PAI-1 marker of decreased fibrinolisis and atherosclerosis by measuring I...

Background/objectives: The aim of the study was to assess hypothalamic–pituitary–adrenal (HPA) axis in patients with chronic fatigue syndrome (CFS).Design and methods: Twenty-three consecutive patients who fulfilled centers for disease control (CDC) criteria for CFS and twenty healthy controls were included in the study. Low dose ACTH test (1mcg of synthetic adrenocorticotropic hormone Synacthen) and insulin tolerance test (ITT) were done and b...